نتایج جستجو برای: Hydrotropic agent

تعداد نتایج: 253418  

Journal: :journal of the iranian chemical research 0
mukesh chandra sharma school of pharmacy, devi ahilya vishwavidyalaya, indore (m.p) 452001, india smita sharma department of chemistry chodhary dilip singh kanya mahavidyalya, bhind (m.p)477001, india

two simple, accurate and precise methods for simultaneous estimation of esomeprazole and itopride in bulk drug and tablet dosage form have been described. method-a employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. method -b is absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.beer’s law was obeyed in the con...

2011
R K Jat R. C. Chhipa

Several techniques are used to increase the aqueous solubilities of poorly water soluble drugs. Hydrotropic solubilization technique is one of them. In the present investigation hydrotropic solution of Urea (10M) has been used as a solubilizing agent to solubilize poorly water soluble drug. Fluvoxamine maleate shows maximum absorbance at 271 nm. Beer’s law was obeyed in the concentration range ...

Journal: :Advanced pharmaceutical bulletin 2013
Ruchi Jain Nilesh Jain Deepak Kumar Jain Surendra Kumar Jain

PURPOSE Analysis of drug utilized the organic solvent which are costlier, toxic and causing environment pollution. Hydrotropic solution may be a proper choice to preclude the use of organic solvents so that a simple, accurate, novel, safe and precise method has been developed for estimation of poorly water soluble drug Entacapone (Water Solubility-7.97e-(02) g/l). METHODS Solubility of entaca...

Journal: :European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006
M P Evstigneev V P Evstigneev A A Hernandez Santiago D B Davies

The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously. A model for analysis of ternary systems, which takes into account all possible complexes between the molecules, has been developed and tested with experimental NMR data on ...

2010
R. K. MAHESHWARI S. R. BISHNOI

Various techniques are employed to enhance the aqueous solubility of poorly watersoluble drugs and hydrotropic solubilization is one of them. In the present investigation, hydrotropic solution of ibuprofen sodium (0.5M) was employed as solubilizing agent to solubilize the poorly water-soluble drug, ornidazole from fine power of its tablets for spectrophotometric determination. Ornidazole shows ...

2014
Sindhu Abraham Rajamanickam Deveswaran Sharon Furtado Srinivasan Bharath Varadharajan Madhavan

Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. It is used in osteoarthritis and rheumatoid arthritis; and in treatment of postoperative pain and primary dysmenorrhoea. Lornoxicam is completely insoluble in water but soluble in alkaline solutions. Hydrotropic solubilization is a technique used to i...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2004
Yong Woo Cho Jaehwi Lee Sang Cheon Lee Kang Moo Huh Kinam Park

A new experimental method for in vitro release studies of poorly soluble drugs from polymeric micelle systems was developed using a hydrotropic agent, sodium salicylate. It is difficult to maintain a good sink condition for poorly water-soluble drugs, such as paclitaxel (PTX), because of their low aqueous solubility. In this study, a good sink condition for PTX was achieved by using aqueous sod...

2009
R. K. Maheshwari G. Wanare Nitika Chahar Prajakta Joshi Nishi Nayak

In the present investigation 0.5 M ibuprofen sodium solution has been used as hydrotropic solubilizing agent for naproxen, a poorly water-soluble drug and in it there was more than 350 fold enhancement in the solubility of naproxen as compared to the solubility in distilled water. Therefore, this hydrotropic solution was employed to extract out the drug from its tablet dosage form for quantitat...

2012
Tomoka Takatani-Nakase Erika Tokuyama Megumi Komai Koichi Takahashi

BACKGROUND Transcutaneous immunization (TCI) is a novel vaccination strategy, which is expected to have therapeutic applications. However, to develop effective TCI systems, a simple, non-invasive and safe transdermal formulation is required. This study developed a novel TCI system utilizing the co-administration of a liposoluble absorption enhancer, propylene glycol monocaprylate (PGMC) and hyd...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2005
Kang Moo Huh Sang Cheon Lee Yong Woo Cho Jaehwi Lee Jae Hyun Jeong Kinam Park

Hydrotropic polymer micelle system has been developed for delivery of poorly water-soluble drugs such as paclitaxel. Hydrotropic polymers based on N,N-diethylnicotinamide were synthesized and used as a hydrophobic block for constructing amphiphilic block copolymers. The hydrotropic block copolymers self-assembled to form micelles in aqueous media. The size of the prepared polymer micelles was i...

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